Medication adverse reactions in patients with cancer assisted in “Conrado Benítez” Teaching Cancer Hospital
Keywords:
medication, adverse reaction, pharmacovigilance, secondary health care.Abstract
A descriptive and cross-sectional study of 42 patients with adverse reactions to medications, assisted in “Conrado Benítez” Teaching Oncological Hospital of Santiago de Cuba was carried out during the second semester of 2016, aimed at determining the most frequent ones, as well as the drugs that had a higher effect on such reactions. In the series, most of these reactions were notified by the graduates in pharmacy (76.2%) and among them the leukopenia, pruritic eruption, shivering and tachycardia were the most notable. On the other hand, the predominant pharmacological groups were the antineoplastic and immunosupressant ones, of which cyclophosphamide was the drugs of more incidence, followed by red blood cells concentrate and calcium gluconate, respectively.
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References
2. Chabner BA, Chabner Thompson E, Harvard Medical School, Massachusetts General Hospital Cancer Center, New York Group for Plastic Surgery. Principios del tratamiento oncológico. 11 ed. El Manual Merck. Barcelona: Elsevier; 2007.
3. Real Decreto 577/2013, de 26 de julio, por el que se regula la farmacovigilancia de medicamentos de uso humano, 2013 [citado 16 Abr 2016]. Disponible en: https://www.boe.es/buscar/pdf/2013/BOE-A-2013-8191-consolidado.pdf
4. Fernández Regueiro R, Fonseca Aizpuru E, López Colina G, Álvarez Uría A, Rodríguez Ávila E, Morís de la Tassa J. Prescripción inadecuada y efectos adversos a medicamentos en pacientes de edad avanzada. Rev Clin Esp. 2011;211(8):400-6.
5. Delgado Silveira E, Muñoz García M, Montero Errasquin B, Sánchez Castellano C, Gallagher PF, Cruz Jentoft AJ. Prescripción inapropiada de medicamentos en los pacientes mayores: los criterios STOPP/START. Rev Esp Geriatr Gerontol. 2009;44 (5):273-9.
6. National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology. Antiemesis. Versión 2.2014 [citado 16 Abr 2016]. Disponible en: http://www.prolekare.cz/dokumenty/Antiemetikum_guidelines.pdf
7. Sociedad Española de Farmacia Hospitalaria. Guía de interacciones farmacológicas de citostáticos. Madrid: SEFH; 2014.
8. Pérez Matera J. Neutropenia febril en pediatría. Curso continuo de actualización en pediatría. CCAP. 2013 [citado 16 Abr 2016]; 12(3). Disponible en: http://www. scp.com.co/precop-old/precop_files/ ano12/TERCERO/ neutropenia_febril.pdf
9. Ducasse K, Fernández JP, Salgado C, Alvarez AM, Avilés CL, Becker A, et al. Characterization of episodes of febrile neutropenia in children with acute myeloid leukemia and acute lymphoblastic leukemia. Rev Chilena Infectol. 2014;31 (3):333-8.
10. Avilés Robles M, Ojha RP, González M, Ojeda Diezbarroso K, Dorantes Acosta E, Jackson BE, et al. Bloodstream infections and inpatient length of stay among pediatric cancer patients with febrile neutropenia in Mexico City. Am J Infect Control. 2014;42(11):1235-7.
11. Haile DB, Ayen WY, Tiwari P. Prevalence and assessment of factors contributing to adverse drug reactions in wards of a tertiary care hospital, India. Ethiop J Health Sci. 2013;23(1):39-48.
12. Ponte ML, Ragusa M, Armenteros Ch, Wachs A. Relevancia de la farmacovigilancia hospitalaria en la práctica médica actual. Medicina (B. Aires). 2013;73(1):35-8.
13. Debesa García F, Jiménez G, Ávila Pérez J, González B, Pérez Peña J, Fernández Argüelles R. Principales resultados del sistema cubano de farmacovigilancia en el año 2004. Rev Cubana Farm. 2005 [citado 16 Abr 2016]; 39(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152005000300005
14. Szlejf C, Farfel JM, Curiati JA, de Barros Couto E, Jacob Filho W, Soares Azevedo R. Medical adverse events in elderly hospitalized patients: a prospective study. Clinics (Sao Paulo). 2012;67(11):1247-52.
15. Berthoux E, Dufour C, Raharisondraibe E, Bonnefoy M. Preventable drug events in acute geriatric unit. Geriatr Psycol Neuropsychiatr Vieil. 2013;11(1):15-20.
16. Marcum ZA, Amuan ME, Hanlon JT, Aspinall SL, Handler SM, Ruby CM, et al. Prevalence of unplanned hospitalizations caused by adverse drug reactions in older veterans. J Am Geriatr Soc. 2012; 60(1):34-41.
17. Casas Gross S, Gross Fernández M, Ramos Hernández L, Herrero Aguirre H, Malo de Molina RR. Reacciones adversas a medicamentos en el Hospital Provincial Docente Clinicoquirúrgico “Saturnino Lora Torres”. MEDISAN. 2016 [citado 16 Abr 2015];20(8). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192016000800004
18. Hakkarainen KM, Hedna K, Petzold M, Hägg S. Percentage of patients with preventable adverse drug reactions and preventavility of adverse drug reactions-A meta-analysis. Plos One. 2012;7(3):1-9.
19. Cardona R, Rojas W. Mecanismos básicos de las alergias. En: Rojas W, Aristizábal B, Anaya JM, Cano LH, Gómez LM, Lopera D. Inmunología de Rojas. 17 ed. Madrid: Editorial CIB; 2015.p.409-19.
20. Fariñas Acosta L. Las mujeres viven más que los hombres, pero con peor salud. Periódico Granma, 16 de julio de 2017 [citado 28 Jul 2017]. Disponible en: http://www.granma.cu/todo-salud/2017-07-16/las-mujeres-viven-mas-pero-tienen-peor-salud-16-07-2017-23-07-03
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