Some specificities on external hemangiomas in children
Keywords:
hemangioma, children, propranolol, neoplasm of vascular tissue.Abstract
Hemangiomas are benign vascular tumors with very specific biological characteristics during childhood; these tumors can be located in organs, and receive the name of "internal", or in head, neck, trunk and extremities that are denominated "external", which grow to a variable speed. Some clinical epidemiological particularities of external hemangiomas were exposed with this work, such as their classification, diagnosis and clinical course. Also, there is a reference to some aspects related to the effectiveness of propranolol as therapeutic proposal of first election in children and the results of some authors in this respect are presented, most of which coincide as for its use as first line medication.
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References
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6. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982; 69(3): 412-20.
7. Püttgen KB. Diagnosis and management of infantile hemangiomas. Pediatr Clin North Am. 2014; 61(2):383-402.
8. Dubois J, Patriquin HB, Garel L, Powell J, Filiatrault D, David M, et al. Soft-tissue hemangiomas in infants and children: diagnosis using Doppler sonography. AJR Am J Roentgenol. 1998; 171(1): 247-52.
9. El Fekih N, Hafsi W, Jones M, Zine N, Khaled A, Zeglaoui F, et al. Propranolol in the treatment of infantile haemangioma in Tunisia. Ann Dermatol Venereol. 2013; 140(6-7): 465-6.
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11. Sharma VK, Fraulin FO, Dumestre DO, Walker L, Harrop AR Can J. Beta blockers for the treatment of problematic hemangiomas. Plast Surg. 2013; 21(1):23-8.
12. Bauman NM, McCarter RJ, Guzzetta PC, Shin JJ, Oh AK, Preciado DA, et al. Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2014; 140(4): 323-30.
13. Al Dosari S, Riad H. Ulcerated nasal infantile haemangioma treated by oral propranolol. Dermatol Online J. 2013; 19(5):18298.
14. Ji Y, Li K, Xiao X, Zheng S, Xu T, Chen S. Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells. J Pediatr Surg. 2012; 47(12): 2216-23.
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16. Zhang L, Mai HM, Zheng J, Zheng JW, Wang YA, Qin ZP, et al. Propranolol inhibits angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell. Int J Clin Exp Pathol. 2013; 7(1):48-55.
17. Ma X, Zhao T, Ouyang T, Xin S, Ma Y, Chang M. Propranolol enhanced adipogenesis instead of induction of apoptosis of hemangiomas stem cells. Int J Clin Exp Pathol. 2014; 7(7):3809-17.
18. Liu X, Tai M, Qin Z, Li K, Ge C. Clinical analysis for treatment of 1 080 cases of infantile hemangiomas with oral propranolol. Zhonghua Yi Xue Za Zhi. 2014; 94(24):1878-81.
19. De Graaf M, Breur JM, Raphaël MF, Vos M, Breugem CC, Pasmans SG. Adverse effects of propranolol when used in the treatment of hemangiomas: A case series of 28 infants. J Am Acad Dermatol. 2011; 65(2): 320-7.
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21. Sans V, de la Roque ED, Berge J, Grenier N, Boralevi F, Mazereeuw-Hautier J, et al. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics. 2009; 124(3): 423-31.
22. Baselga E. Hemangiomas de la infancia: pasado, presente y futuro del tratamiento con Propranolol. Actas Dermosifiliogr. 2011; 102(7): 484–6.
23. Mc Gee P, Miller S, Black C, Hoey S. Propranolol for infantile haemangioma: A Review of Current Dosing Regime in a Regional Paediatric Hospital. Ulster Med J. 2013; 82(1): 16-20.
24. Moredo Romo E, Pastrana Fundora FM. Experiencia en el tratamiento de los hemangiomas infantiles con propranolol de producción nacional. Rev Cubana Pediatr. 2014; 86(2): 147-58.
25. Albornoz López del Castillo CM, Oliva Céspedes CM, Bueno Rivero R, Arranz Pozo JC. Propranolol en el tratamiento de los hemangiomas infantiles complicados. AMC. 2014 [citado 14 Jul 2017]; 18(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552014000100015
26. Berdión Sevilla E, Hernández Viel V. El propranolol revoluciona el tratamiento de los hemangiomas en la infancia. MEDISAN. 2013 [citado 14 Jul 2017]; 17(7). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192013000700018
27. Sethuraman G, Yenamandra VK, Gupta V. Management of infantile hemangiomas: current trends. J Cutan Aesthet Surg. 2014; 7(2):75-85.
28. Luo Y, Zeng Y, Zhou B, Tang J. A retrospective study of propranolol therapy in 635 infants with infantile hemangioma. Pediatr Dermatol. 2015; 32(1): 151-2.
29. Hermans DJ, Bauland CG, Zweegers J, van Beynum IM, van der Vleuten CJ. Propranolol in a case series of 174 patients with complicated infantile haemangioma: indications, safety and future directions. Br J Dermatol. 2013; 168(4):837-43.
30. Léauté-Labrèze C, Harper JI, Hoeger PH. Infantile haemangioma. Lancet. 2017; 390(10089): 85–94.
2. Hanggstrom AN, Drolet BA, Beselga E, Chamlin SL, Garzon MC, Horii KA, et al. Prospective study of infantile hemangioma: clinical characteristics, predicting complications and treatment. Pediatrics. 2006; 118(6): 882-7.
3. Gunturi N, Ramgopal S, Balagopal S, Scott JX. Propranolol therapy for infantile hemangioma. Indian Pediatr. 2013; 50(3): 307-13.
4. Laranjo S, Costa G, Paramés F, Freitas I, Martins JD, Trigo C, et al. The role of propranolol in the treatment of infantile hemangioma. Rev Port Cardiol. 2014; 33(5): 289-95.
5. Yilmaz L, Dangoisse C, Semaille P. Infantile hemangioma and propranolol: a therapeutic "revolution". Literature review. Rev Med Brux. 2013; 34(6): 479-84.
6. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982; 69(3): 412-20.
7. Püttgen KB. Diagnosis and management of infantile hemangiomas. Pediatr Clin North Am. 2014; 61(2):383-402.
8. Dubois J, Patriquin HB, Garel L, Powell J, Filiatrault D, David M, et al. Soft-tissue hemangiomas in infants and children: diagnosis using Doppler sonography. AJR Am J Roentgenol. 1998; 171(1): 247-52.
9. El Fekih N, Hafsi W, Jones M, Zine N, Khaled A, Zeglaoui F, et al. Propranolol in the treatment of infantile haemangioma in Tunisia. Ann Dermatol Venereol. 2013; 140(6-7): 465-6.
10. Lucas Laguna R. Angiomas y malformaciones vasculares, ¿qué debo saber? En: AEPap. Curso de actualización pediatría 2013. Madrid: Exlibris Ediciones; 2013. p. 49-56.
11. Sharma VK, Fraulin FO, Dumestre DO, Walker L, Harrop AR Can J. Beta blockers for the treatment of problematic hemangiomas. Plast Surg. 2013; 21(1):23-8.
12. Bauman NM, McCarter RJ, Guzzetta PC, Shin JJ, Oh AK, Preciado DA, et al. Propranolol vs prednisolone for symptomatic proliferating infantile hemangiomas: a randomized clinical trial. JAMA Otolaryngol Head Neck Surg. 2014; 140(4): 323-30.
13. Al Dosari S, Riad H. Ulcerated nasal infantile haemangioma treated by oral propranolol. Dermatol Online J. 2013; 19(5):18298.
14. Ji Y, Li K, Xiao X, Zheng S, Xu T, Chen S. Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells. J Pediatr Surg. 2012; 47(12): 2216-23.
15. Léauté-Labréze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008; 358(24): 2649-51.
16. Zhang L, Mai HM, Zheng J, Zheng JW, Wang YA, Qin ZP, et al. Propranolol inhibits angiogenesis via down-regulating the expression of vascular endothelial growth factor in hemangioma derived stem cell. Int J Clin Exp Pathol. 2013; 7(1):48-55.
17. Ma X, Zhao T, Ouyang T, Xin S, Ma Y, Chang M. Propranolol enhanced adipogenesis instead of induction of apoptosis of hemangiomas stem cells. Int J Clin Exp Pathol. 2014; 7(7):3809-17.
18. Liu X, Tai M, Qin Z, Li K, Ge C. Clinical analysis for treatment of 1 080 cases of infantile hemangiomas with oral propranolol. Zhonghua Yi Xue Za Zhi. 2014; 94(24):1878-81.
19. De Graaf M, Breur JM, Raphaël MF, Vos M, Breugem CC, Pasmans SG. Adverse effects of propranolol when used in the treatment of hemangiomas: A case series of 28 infants. J Am Acad Dermatol. 2011; 65(2): 320-7.
20. Janmohamed SR, de Laat PC, Madern GC, Dorresteijn EM, Jan Danser AH, Oranje AP. Treating hemangioma of infancy with beta-blockers: is there really a risk of hypotension? J Am Acad Dermatol. 2012; 67(2):315-6.
21. Sans V, de la Roque ED, Berge J, Grenier N, Boralevi F, Mazereeuw-Hautier J, et al. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics. 2009; 124(3): 423-31.
22. Baselga E. Hemangiomas de la infancia: pasado, presente y futuro del tratamiento con Propranolol. Actas Dermosifiliogr. 2011; 102(7): 484–6.
23. Mc Gee P, Miller S, Black C, Hoey S. Propranolol for infantile haemangioma: A Review of Current Dosing Regime in a Regional Paediatric Hospital. Ulster Med J. 2013; 82(1): 16-20.
24. Moredo Romo E, Pastrana Fundora FM. Experiencia en el tratamiento de los hemangiomas infantiles con propranolol de producción nacional. Rev Cubana Pediatr. 2014; 86(2): 147-58.
25. Albornoz López del Castillo CM, Oliva Céspedes CM, Bueno Rivero R, Arranz Pozo JC. Propranolol en el tratamiento de los hemangiomas infantiles complicados. AMC. 2014 [citado 14 Jul 2017]; 18(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-02552014000100015
26. Berdión Sevilla E, Hernández Viel V. El propranolol revoluciona el tratamiento de los hemangiomas en la infancia. MEDISAN. 2013 [citado 14 Jul 2017]; 17(7). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30192013000700018
27. Sethuraman G, Yenamandra VK, Gupta V. Management of infantile hemangiomas: current trends. J Cutan Aesthet Surg. 2014; 7(2):75-85.
28. Luo Y, Zeng Y, Zhou B, Tang J. A retrospective study of propranolol therapy in 635 infants with infantile hemangioma. Pediatr Dermatol. 2015; 32(1): 151-2.
29. Hermans DJ, Bauland CG, Zweegers J, van Beynum IM, van der Vleuten CJ. Propranolol in a case series of 174 patients with complicated infantile haemangioma: indications, safety and future directions. Br J Dermatol. 2013; 168(4):837-43.
30. Léauté-Labrèze C, Harper JI, Hoeger PH. Infantile haemangioma. Lancet. 2017; 390(10089): 85–94.
Published
2018-03-08
How to Cite
1.
Chércoles Cazate LE, Díaz Socarrás FJ. Some specificities on external hemangiomas in children. MEDISAN [Internet]. 2018 Mar. 8 [cited 2025 Jun. 3];22(3). Available from: https://medisan.sld.cu/index.php/san/article/view/1881
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Biomedical Communication
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