Humoral characteristics of head and neck tumors in patients treated with nimotuzumab

Authors

  • Lisandra Roca Serra Hospital Oncológico Docente Provincial "Conrado Benítez García", Universidad de Ciencias Médicas, Santiago de Cuba
  • María Cristina Céspedes Quevedo Hospital Oncológico Docente Provincial "Conrado Benítez García", Universidad de Ciencias Médicas, Santiago de Cuba
  • María Caridad Ricardo Cobas Hospital Oncológico Docente Provincial "Conrado Benítez García", Universidad de Ciencias Médicas, Santiago de Cuba
  • Leonor Serra Pérez Policlínico Universitario “Julián Grimau García”, Santiago de Cuba
  • Ana Margarita Vinent Céspedes Hospital Provincial Docente Clinicoquirúrgico “Saturnino Lora Torres”, Universidad de Ciencias Médicas, Santiago de Cuba

Keywords:

monoclonal antibody, nimotuzumab, cancer, secondary health care.

Abstract

An observational, descriptive and retrospective study of 36 patients included in the (phase IV) clinical trial "Security and effectiveness of nimotuzumab in head and neck tumors" was carried out. It was developed at "Conrado Benítez" Cancer Hospital in Santiago de Cuba, from January, 2013 to December, 2016, aimed at identifying the humoral characteristics of these tumors in the affected patients. The Student t test was used with a statistical significance of p <0.05. There was a prevalence of the male sex in older than 60 years, the clinical adverse effects and the pharynx tumor; the clinical stage III and the well differentiated epidermoid carcinoma were the most frequent findings. There were no statistically significant differences among the laboratory parameters before and during the combined treatment with nimotuzumab. This medication constituted a sure, advantageous and feasible therapeutic alternative as part of the conventional therapeutic plan in assistance conditions. 

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Author Biography

Lisandra Roca Serra, Hospital Oncológico Docente Provincial "Conrado Benítez García", Universidad de Ciencias Médicas, Santiago de Cuba

Espedcialista de 1er grado de laboratorio clìnico

References

1. Fernández Pérez MD, Regueira Betancourt SM, Torres Fernández M. Factores de riesgo modificables en algunos tipos de cáncer. Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta. 2016 [citado 8 Feb 2017]; 41 (11). Disponible en: http://revzoilomarinello.sld.cu/index.php/zmv/article/view/940/pdf_349

2. Suarez García R, Pérez Martínez CY, Fernández Rojas L, Pérez Pupo A. Caracterización de adultos mayores con cáncer de cabeza y cuello. CCM. 2013 [citado 20 Nov 2016]; 17 (2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1560-43812013000200002

3. Mehanna H, Paleri V. Epidemiología, presentación y prevención de cáncer de cabeza y cuello. Revisión de las presentaciones frecuentes, estudios comunes y nuevas técnicas de diagnóstico. Detección y prevención. BMJ. 2010; 341:4684.

4. Zerecero Carreón O, Valle Mendiola A, Weiss Steider B, Soto Cruz I. El receptor para el factor de crecimiento epidérmico (EGFR) y su relación con el cáncer. Revista Especializada en Ciencias de la Salud. 2012 [citado 8 Feb 2017]; 15 (1). Disponible en: http://www.medigraphic.com/pdfs/vertientes/vre-2012/vre121b.pdf

5. Fuenmayor J, Gamez Hoyos R, Montaño Ramón F. Anticuerpos monoclonales en el tratamiento del cáncer. Terapia dirigida para tumores sólidos. Rev Venez Oncol. 2013; 25 (4): 236-54.

6. Alfonso Orta I, Alonso Carbonell L, Alonso Garbán P, Broche Villareal L, Calvo
Barbado DM, González Ricardo Y, et al. Formulario Nacional de Medicamentos.
4 ed. La Habana: ECIMED; 2014. p. 325-6.

7. Pérez Delgado N, Urgellés Rodríguez E, Acosta Calderín MM, Álvarez González A. Comportamiento clínico-epidemiológico de cáncer de cabeza y cuello en provincia de Guantánamo. Rev Inf Cient. 2014 [citado 20 Nov 2016]; 83 (1). Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/view/981/1936

8. Ramakrishnan MS, Eswaraiah A, Crombet T, Piedra P, Saurez G, Iyer H, et al. Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin. MAbs. 2009 [citado 25 Mar 2015]; 1 (1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715181/

9. Osorio Rodríguez M, Cruz Rivero T, del Castillo Bahi R, Roca Muchuli C, Azcue Bilbao M, Neninger Vinageras E, et al. Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck. Cancer Biol Ther. 2010; 9 (5):343-9.

10. Huang XD, Yi JL GL, Xu GZ JJ, et al. Multi-center phase II clinical trial of humanized anti-epidermal factor receptor monoclonal antibody h-R3 combined with radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Zhonghua Zhong Liu Zhi. 2007; 29 (3):197-201.

11. Bacallao Méndez RA, Crombet Ramos T, Dávalos Iglesias JM, Mañalich Comas R, Llerena Ferrer B, Gutiérrez García F. Niveles séricos de magnesio en pacientes oncológicos tratados con nimotuzumab. Rev Cubana med. 2015 [citado 14 Jun 2017]; 54 (2): 139-150. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232015000200005

12. Cimaher (nimotuzumab). Resumen de las características del producto. La Habana: CIMAB S. A; 2013.

13. Nimotuzumab. Rev Cubana Farm. 2012 [citado 14 Jun 2017] ; 46 ( 3 ). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152012000300011

14. Saurez Martínez G, Salva Camaño SN, Piedra Sierra P, Iglesias Castillo B, Toledo Jiménez C, Salomón Cardona MT, et al. Seguridad y efectividad del nimotuzumab en los pacientes con tumores gliales malignos. Rev Cubana Neurol Neurocir. 2015; 5 (2):123-32.

15. Diaz Miqueli A, Saurez Martinez G. Nimotuzumab as a radiosensitizing agent in the treatment of high grade glioma: challenges and opportunities. Onco Targets Ther. 2013 [citado 25 Mar 2015]; 6. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729249/

16. Solomón MT, Selva JC, Figueredo J, Vaquer J, Toledo C, Quintanal N, et al. Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial. BMC Cancer. 2013 [citado 25 Mar 2015];13. Disponible en:
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-299

17. Aguilera Calvo N, del Cristo Domínguez IS, Muñoz Morejón Y, Palomino Machado L, Macías Abraham A. Evaluación de la seguridad del nimotuzumab en pacientes con cáncer de pulmón de células no pequeñas portadores de metástasis cerebral. Rev Electrónica Dr. Zoilo E. Marinello Vidaurreta. 2015 [citado 14 Ene 2017]; 40 (9). Disponible en: http://revzoilomarinello.sld.cu/index.php/zmv/article/view/311/html_87

18. Okamoto W, YoshinoT, TakahashiT, Okamoto I, Ueda S, Tsuya A, et al. A phase I, pharmacokinetic and pharmacodynamic study of nimotuzumab in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2013; 72 (5):1063–71.

19. Lu M, Wang X, Shen L, Jia J, Gong J, Li J, et al. Nimotuzumab plus paclitaxel and cisplatin as the first line treatment for advanced esophageal squamous cell cancer: A single centre prospective phase II trial. Cancer Sci. 2016 [citado 14 Ene 2017]; 107 (4). Disponible en: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12894

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Published

2018-05-15

How to Cite

1.
Roca Serra L, Céspedes Quevedo MC, Ricardo Cobas MC, Serra Pérez L, Vinent Céspedes AM. Humoral characteristics of head and neck tumors in patients treated with nimotuzumab. MEDISAN [Internet]. 2018 May 15 [cited 2025 Jun. 3];22(5). Available from: https://medisan.sld.cu/index.php/san/article/view/1983

Issue

Vol. 22 No. 5 (2018): MEDISAN

Section

Original Articles

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