Topical use of plasmatic platelets in patients with superficial punctuated queratitis
Keywords:
superficial punctuated queratitis, plasmatic platelets, corneal scaringAbstract
A clinical, prospective, interventionist and comparative study of 41 patients (31 eyes) with diagnosis of superficial punctate queratitis —selected by simple random sampling—, assisted in "Dr. Antonio María Béguez Caesar" Southern Teaching Pediatric Hospital in Santiago de Cuba was carried out from November, 2016 to May, 2017, with the objective of demonstrating the effectiveness of the topical treatment of plasmatic platelets in them with eyewash, for which 2 groups were formed: group A with conventional topical treatment, and group B with the same therapy plus eyewash with rich platelets plasm. The patients had clinical follow- up at two and four weeks of having applied the treatment. In most of the patients of group B the time of corneal scaring was of 7 days and that of cure of 2 weeks; so that the effectiveness of this autologous eyewash was demonstrated in the corneal scaring, without risk of immunological reaction and with low economic cost.
Downloads
References
1. Biswell R. Córnea. En: Kanski BB. Oftalmología clínica. 8 ed. Madrid: Elsevier; 2012. p. 168–210.
2. Anitua E, Muruzabal F, Pino A, Merayo Lloves J, Orive G. Biological stability of plasma rich in growth factors eye drops after storage of 3 months. Córnea. 2013; 32(10):1380–6.
3. Anitua E, Muruzabal F, Alcalde I, Meray Lloves J, Orive G. Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery. Exp Eye Res. 2013; 115:153-61.
4. Muñoz CWR, Luna MI, Vázquez ML, García CK, Martínez PM. Aplicación de plasma rico en plaquetas combinado con injerto de membrana amniótica en el tratamiento de adelgazamiento corneales. Rev Mexicana Oftalmol. 2013; 87(3): 158–64.
5. González Iglesias AI, Fernández Delgado N, Forrellat Barrios M, Hernández Ramírez P. Caracterización de los concentrados plaquetarios utilizados en Medicina Regenerativa. Rev Cubana Hematol Inmunol Hemoter. 2014 [citado 12/10/2017]; 30(2): 171-8. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-02892014000200010
6. González Iglesias AJ, Fernández Delgado DN, González Suárez T. Colirio de lisado plaquetario en el tratamiento del ojo seco. Rev Cubana Hematol, Inmunol Hemoter. 2015; 31(2):214-6.
7. Carrillo Mora P, González Villalva A, Macías Hernández SI, Pineda Villaseñor C. Plasma rico en plaquetas. Herramienta versátil de la medicina regenerativa Cir Cir. 2013; 81(1):74-82.
8. Monzón LC, Caceres YN. Plasma rico en plaquetas: una alternativa terapéutica versátil en enfermedades oftálmicas. Medicentro Electrónica. 2017 [citado 01/12/2017]; 21(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30432017000200002
9. Ogawa Y, Okamoto S, Mori T, Yamada M, Mashima Y, Watanabe R, et al. Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Bone Marrow Trasnplant. 2003; 31: 579-83.
10. Serrano García Y, Vejerano Duany AA, González Fernández MC. El suero autólogo en el tratamiento de las quemaduras corneoconjuntivales. Rev Electrónica “Dr. Zoilo E. Marinello Vidaurreta”. 2016 [citado 12/10/2017]; 41(10). Disponible en: http://revzoilomarinello.sld.cu/index.php/zmv/article/view/859
11. Arnalich F, Rodriguez AE, Luque Rio A, Alio JL. Solid Platelet Rich Plasma in Corneal Surgery. Ophthalmol Ther. 2016 [citado 12/10/2017]; 5(1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909678/
12. Fernández Delgado N, Hernández Ramírez P, Forrellat Barrios M. Espectro funcional de las plaquetas. De la hemostasia a la Medicina Regenerativa. Rev Cubana Hematol Inmunol Hemoter. 2012; 28(3): 200-16.
13. Muñoz – Cruz WR, Luna MI, Maya VL, Carmona GK, Pardo MM. Aplicación de plasma rico en plaquetas combinado con injerto de membrana amniótica en el tratamiento de adelgazamiento corneal. Rev Mexicana Oftalmol. 2013; 87(3):158-64.
14. Anitua E, Alkhraisatb MH, Orive G. Perspectives and challenges in regenerative medicine using plasma rich in growth factors. J Control Rel. 2012; 157(1): 29–38.
15. Cárdenas Monzón L, Negrin Cáceres Y. Plasma rico en plaquetas: una alternativa terapéutica vérsatil en enfermedades oftálmicas. Medicentro Electrónica. 2017 [citado 1/12/2017]; 21(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1029-30432017000200002
16. Barría N, Haro F, Henriquez E, Unda M. Concentrados plaquetarios y usos en oftalmología. Rev Medicina y humanidades. 2017 [citado 1/12/2017]; (Número monográfico de Oftalmología). Disponible en: http://www.medicinayhumanidades.cl/ediciones/2017/especial_oftalmologia/04_CONCENTRADOS%20PLAQUETARIOS.pdf
17. Hartwig D, Harloff S, Liu L, Schlenke P, Wedel T, Geerling G. Epitheliotrophic capacity of a growth factor preparation produced form platelet concentrates on corneal epithelial cells: a potencial agent for the treatment of ocular surface defects? Transfusion. 2004; 44(12): 1724-31.
18. Hartwig D, Herminghaus P, Wedel T, Liu L, Schlenke P, Dibbelt L, et al. Topycal treatment of ocular surface defects: comparison of epitheliotrophic capacity of fresh frozen plasma and serum on corneal epithelial cells in an in vitro cell culture model. Tranfus Med. 2005; 15(2): 107-13.
Published
How to Cite
Issue
Section
License
All the articles can be downloaded or read for free. The journal does not charge any amount of money to the authors for the reception, edition or the publication of the articles, making the whole process completely free. Medisan has no embargo period and it is published under the license of Creative Commons, International Non Commercial Recognition 4.0, which authorizes the copy, reproduction and the total or partial distribution of the articles in any format or platform, with the conditions of citing the source of information and not to be used for profitable purposes.