Some clinical and humoral aspects of liver failure in children and adolescents

Authors

Keywords:

child, adolescent, acute liver failure, brain disease, hepatotropic virus.

Abstract

Introduction: The acute liver failure is an entity of multifactorial origin that is presented in previously healthy children and has direct repercussion in the synthesis, clotting and purification functions. 

Objective: To characterize children with acute liver failure according to clinical and humoral variables. 

Methods: A retrospective and descriptive study of 19 patients with diagnosis of acute liver failure was carried out, they were assisted in the Pediatric Intensive Cares Unit of the   Southern Children Hospital in Santiago de Cuba, from April, 1998 to the same month in 2018, for which theoretical and statistical methods were used. 

Results: In the case material there was a prevalence of the female sex (57.9 %), the mean age was 5 years and the infection constituted the most common cause (73.7 %). The hepatotropic virus as the hepatitis A were the most frequent. The complications of more observance were the respiratory alkalosis (63.1 %), the multiorganic dysfunction (42.1 %) and the liver brain disease (31.6 %). The low figures of cholesterol and the prothrombin time higher than 20 seconds were associated with a greater lethality.  

Conclusions: In the patients younger than one year the non hepatotropic virus constituted the most frequent origin in this disease. 

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Author Biography

Pablo Antonio Hernández Dinza, Hospital Docente Infantil Sur Dr. Antonio María Béguez César, Universidad de Ciencias Médicas. Santiago de Cuba

Máster en enfermedades infecciosas. Especialista de segundo grado en terapia intensiva pediátrica. Especialista de primer grado en pediatría.Asistente.

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Published

2020-03-19

How to Cite

1.
Hernández Dinza PA, Cabrera Cabrales EA, Guerra Cosme R, Quesada Castillo M, Reifes Martén A. Some clinical and humoral aspects of liver failure in children and adolescents. MEDISAN [Internet]. 2020 Mar. 19 [cited 2025 Jun. 2];24(2):185-97. Available from: https://medisan.sld.cu/index.php/san/article/view/2560

Issue

Vol. 24 No. 2 (2020): marzo-abril

Section

Original Articles

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