Syndrome due to propofol infusion in an adolescent

Authors

Keywords:

adolescent, operation, propofol, syndrome due to propofol, general anesthesia, sedation.

Abstract

The case report of an 18 years adolescent with history of apparent health is described. He was assisted in the emergency service of Roberto Rodríguez Fernández Teaching General Hospital from Morón, Ciego de Ávila, with suggestive symptoms of acute appendicitis, reason why he was surgically intervened. Once finished the procedure he had a cardiac arrest, which was interpreted as a syndrome due to propofol. It was decided to referred him to the Intensive Cares Unit, where he had a favorable clinical course, with improvement of all parameters.  Six days later he was transferred to the Intermediate Cares Unit and later on he was discharged from the hospital institution without complications.   

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References

1. Krajčová A, Waldauf P, Anděl M, Duška F, Access O. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care. 2015 [citado 09/04/2019];19:398. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642662/

2. Diprivan® (propofol 1 %) injectable emulsion, USP, 2017 [citado 09/04/2019] Disponible en: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019627s066lbl.pdf

3. EMA. Diprivan® 1 % e 2 % (Propofol). Lake Drive. Ireland: Aspen Pharma; 2017.

4. Van Diepen S, Katz JN, Albert NM, Henry TD, Jacobs AK, Kapur NK, et al. Contemporary Management of Cardiogenic Shock: A Scientific Statement from the American Heart Association. Circulation. 2017 [citado 11/05/2020];136:232-68. Disponible en: https://www.ahajournals.org/doi/full/10.1161/cir.0000000000000525

5. Subirà González A, Fernández Morales M, Sánchez Royo E, Boliart de San Félix Y, Vila Lolo C, et al. Propofol infusion; are high doses always required? Rev Esp Anestesiol Reanim (Engl Ed). 2020 [citado 20/01/2021];67(3):163-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32111374/

6. Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofol infusion syndrome: a estructured literature review and analysis of published case reports. Br J Anaesth. 2019 [citado 09/04/2020]; 122(4):448-59. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30857601/

7. Vollmer JP, Haen S, Wolburg H, Lehmann R, Steiner J, Reddersen S, et al. Propofol Related Infusion Syndrome: Ultrastructural Evidence for a Mitochondrial Disorder. Crit Care Med. 2018 [citado 24/11/2020];46(1):91-4. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29252954/

8. Lonnqvist PA, Bell M, Karlsson T, Wiklund L, Hoglund AS, Larsson L. Does prolonged propofol sedation of mechanically ventilation COVID-19 patients contribute to critically illness myopathy? Br J Anaesth. 2020 [citado 20/01/2021]; 125(3): e334–6. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284264/

9. Walli A, Poulsen TD, Dam M, Børglum J. Propofol Infusion Syndrome in Refractory Status Epilepticus: A Case Report and Topical Review. Case Rep Emerg Med. 2016 [citado 15/06/2020]; 2016. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27493812/

10. Lu L, Xiong W, Zhang Y, Xiao Y, Zhou D. Propofol-induced refractory status epilepticus at remission age in benign epilepsy with centrotemporal spikes: a case report and literature review. Medicine (Baltimore). 2019 [citado 12/07/2021]; 98(27). Disponible en: https://pubmed.ncbi.nlm.nih.gov/31277145/

Published

2021-12-06

How to Cite

1.
Barrio Cruz Y. Syndrome due to propofol infusion in an adolescent. MEDISAN [Internet]. 2021 Dec. 6 [cited 2025 Jun. 2];25(6):1447-55. Available from: https://medisan.sld.cu/index.php/san/article/view/3687