Hyperhomocysteinemia as a Predictive Factor for Inadequate Metabolic Control in Patients with Type II Diabetes Mellitus
Abstract
Introduction: Elevated blood homocysteine levels constitute a consequential risk factor for cardiovascular disease and are part of the complications in diabetic patients with metabolic dyscontrol.
Objective: To determine the predictive magnitude of hyperhomocysteinemia in the emergence of metabolic dyscontrol in patients with type II diabetes mellitus.
Methods: An observational and analytical study was conducted in 100 patients who attended the endocrinology service at the Provincial Center for Diabetic Care in Santiago de Cuba from September 2015 to January 2017, with an equal number of controls. The variables analyzed were: age, sex, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, homocysteine, and metabolic control. Descriptive statistics were used for demographic variables, and the mean and standard deviation were estimated for biochemical variables. Student's t-test was applied to compare the means of the determinations.
Results: It was evidenced that 8 out of every 10 diabetics with high homocysteine levels had metabolic dyscontrol, and that the cause of the imbalance among them was hyperhomocysteinemia, which was feasible for its use.
Conclusions: According to the results of this study, homocysteine should be analyzed in depth as a potential marker of metabolic control in type II diabetes mellitus.
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