Variations in c-reactive protein levels in patients with periodontitis
Keywords:
periodontitis; C-reactive protein; low-grade inflammation; inflammatory markersAbstract
Introduction: Periodontitis is associated with elevated levels of C-reactive protein, which amplify the low-grade inflammatory response and facilitate systemic inflammation.
Objective: To identify variations in C-reactive protein levels in patients with periodontitis before and after periodontal treatment.
Methods: A prospective, longitudinal study was conducted in the Periodontology Department of the Juan Bruno Zayas Alfonso General Hospital in Santiago de Cuba, from July 2024 to April 2025. The non-random, purposive sample consisted of 34 patients diagnosed with periodontitis, who underwent complete periodontal treatment and had their C-reactive protein levels measured before and after treatment. Summary measures included absolute and relative frequencies, as well as statistical parameters such as arithmetic mean and standard deviation, with a significance level set at p < 0.05.
Results: Before periodontal treatment, 47,0 and 44,01 of patients presented moderate-risk and high-risk C-reactive protein levels, respectively. After treatment, patients achieved levels between low and moderate risk, represented by 47,0 and 50,0 % in each group, respectively. The mean variations were significant for all severity grades of periodontitis.
Conclusions: There were significant variations in C-reactive protein levels before and after periodontal treatment, supporting the possibility that controlling periodontal disease may help manage systemic inflammation in general diseases.
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1. Contreras Rengifo A, Giraldo Vásquez D, Pérez L, Moreno Correa SM, Jaramillo Echeverry A, et al. Manual de Microbiología Periodontal. Colombia: Ed. Universidad del Valle. 2022[citado 04/03/2026]. Disponible en: https://books.google.com.cu/books?id=BDinEAAAQBAJ&lr=&hl=es&source=bs_navlinks_s
2. Sojod B, Périer JM, Zalcberg A, Bouzegza S, Halabi BE, Anagnostou F. Enfermedad periodontal y salud general. EMC-Tratado de Medicina. 2022[citado 04/03/2026]; 26(1):1-8. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1636541022460430
3. Miranda BP, da Silva AF, Ascenção J, dos Reis RB, Teixeira MVM, Miglionico MTS, Santos HLC. Relationship Between Periodontal Disease and Systemic Diseases in Non-Human Primates. Veterinary Sciences. 2025[citado 04/03/2026];12(8): 784. Disponible en: https://www.mdpi.com/2306-7381/12/8/784
4. Arguimbau Coll M, Serrano Stefanova A, Jorva García de Casasola C, Egido Moreno S, Omaña Cepeda C, López-López J. Marcadores inflamatorios de la periodontitis y su papel en la inflamación sistémica: revisión sistemática. Av Odontoestomatol. 2025[citado 04/03/2026];41(spe):63-87. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S021312852025000100007&lng=es
5. Tattar R, da Costa B, Neves V. The interrelationship between periodontal disease and systemic health. Br Dent J. 2025[citado 04/03/2026];239: 103–8. Disponible en: https://www.researchgate.net/publication/394078702_The_interrelationship_between_periodontal_disease_and_systemic_health
6. Rehbein Raddatz D. Asociación entre la carga subgingival de Porphyromonas gingivalis y la inflamación sistémica de bajo grado en individuos con periodontitis. [Tesis]. Chile. Universidad de Chile. 2023 [citado 04/03/2026]. Disponible en: https://repositorio.uchile.cl/handle/2250/198817
7. Sáenz San Martín A, Méndez Ocampo P, Gutiérrez Moctezuma I, Amezcua-Guerra LM. Proteína C reactiva, aspectos cardiovasculares de una proteína de fase aguda: una actualización para el médico. Arch. Cardiol. Méx. 2024[citado 04/03/2026]; 94(2): 191-02. Disponible en:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-99402024000200191&lng=es.
8. Cárdenas Valenzuela P, Guzmán Gastelum DA, Valera González E, Cuevas González JC, Zambrano Galván G, García Calderón AG. Principales Criterios de Diagnóstico de la Nueva Clasificación de Enfermedades y Condiciones Periodontales. Int. J. Odontostomat. 2021[citado 04/03/2026];15(1):175-80. Disponible en: https://www.scielo.cl/pdf/ijodontos/v15n1/0718-381X-ijodontos-15-01-175.pdf
9. González ME, Toledo CB, Sarduy L, Morales DR, De la Rosa H, Veitia F, et al. Compendio de Periodoncia. 2da.Ed. La Habana: ECIMED. 2017
10. Sun J, Wang W, Li D, Song J, Chen Z, Chen L, et.al. Association between C Reactive protein and periodontitis in an obese population from the NHANES 2009-2010. BMC Oral Health. 2023[citado 04/03/2026]; 23(1):512. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10362674/pdf/12903_2023_Article_3189.pdf
11. Cruz Ávila J, Hernández Pérez E, González González R, Bologna Molina R, Molina-Frechero N. Periodontal Disease in Obese Patients; Interleukin-6 and C-Reactive Protein Study: A Systematic Review. Dentistry Journal. 2022[citado 04/03/2026]; 10(12): 225. Disponible en: https://www.mdpi.com/2304-6767/10/12/225
12. Escobar Cabrera NV, Pedraza Maquera KI, Castro Allcca D, Acero Mamani VY, Canque Llanqui NS, Barrios Aguilar EA. Estado periodontal y nivel de proteína C-reactiva (PCR) en gestantes del centro de salud Viñani Tacna–2022. Revista médica HHUT. 2024 [citado 04/03/2026]; 17(1):47-50. Disponible en: https://revista.hospitaltacna.gob.pe/index.php/rmhhut/article/view/20
13. Britos MR. Proteína C reactiva como biomarcador de riesgo en pacientes gestantes con periodontitis. RAAO. 2023 [citado 04/03/2026]; 69(2): 26-30. Disponible en: https://www.ateneo-odontologia.org.ar/articulos/lxix02/articulo04.pdf
14. Padilla Cáceres T, Arbildo Vega HI, Caballero Apaza L, Cruzado Oliva F, Mamani Cori V, Cervantes Alagón S. et. al. Association between the risk of preterm birth and low birth weight with periodontal disease in pregnant women: An Umbrella Review. Dent J Basel. 2023[citado 04/03/2026]; 11(3):74-84. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10047843/pdf/dentistry-11-00074.pdf
15. De Freitas Rêgo Bezerra C, Luz de Aquino AR, Costa de Lima K, da Fonte Porto Carreiro A. Proteína C-reactiva ultrasensible en pacientes con y sin periodontitis crónica severa generalizada. Avances en Periodoncia. 2009 [citado 04/03/2026];21(3). Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1699-65852009000300004
16. Aristizábal Gómez PA, Gómez Pinzón MP, Escobar Arregocés F, Velosa Porras J. Periodontopatías y disfunción endotelial. Asociación entre enfermedad periodontal y disfunción endotelial: revisión sistemática de la literatura Rev. Fundac. Juan José Carraro. 2025 [citado 04/03/2026]; 29(50): 37-53. Disponible en: https://pesquisa.bvsalud.org/odontologia/resource/espt/biblio-1636618
17. Han M, Lee W, Ahn S, Kang MH, Hwang HS, Kwon S, et al. Synergistic effect of periodontitis and C-reactive protein levels on mortality: NHANES 2001–2004. PLoS ONE. 2024[citado 04/03/2026];19(10):e0309476. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10047843/pdf/dentistry-11-00074.pdf
18. Pink C, Holtfreter B, Völzke H. Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study.BMC Med. 2023[citado 04/03/2026];21:430. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC10642059/pdf/12916_2023_Article_3139.pdf
19. Jung Hwa L, So Jung M. Relationship between C reactive protein level and periodontitis and systemic diseases. Journal of Periodontogy. 2023[citado 04/03/2026]; 95(5):494-01. Disponible en: https://doi.org/10.1002/JPER.23-000
20. Noland Ferrer B, Mártir González AA, Reynaldo Concepción D, Portal Fernández E. La periodontitis y su asociación con la enfermedad arterial periférica. RCACV. 2025 [citado 04/03/2026];26: 980. Disponible en: https://revangiologia.sld.cu/index.php/ang/article/view/980
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Copyright (c) 2026 Maritza Peña Sisto, Rafael Alberto Clavería Clark , Katiuska Rodríguez Guerrero , Lídice Torres Mahy , Rachel Viviana Cabrera Abalos
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