Clinical features of patients with small-cell lung cancer
Keywords:
small-cell lung cancer, chemotherapy, treatment response, survival.Abstract
A descriptive, longitudinal and retrospective observational study of 46 patients with small-cell lung cancer, diagnosed histopathologically and treated by the Care Group to patients with lung tumors in "Saturnino Lora Torres" Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, was carried out from January, 2002 to December, 2014, aimed at identifying their clinical features and evaluating their global survival. The disease prevailed in the male sex, mainly in the 55 to 74 age group, and its most frequent presentation were the bronchopneumonic and lung infiltrative hilar types, detected in a clinical and radiological way, respectively. On the other hand, the histological diagnostic was obtained mainly through the bronchoscopy with biopsy and the cytological sputum, in a limited stage, and although in most of the patients the carboplatin and etoposide combination could be apply as first line treatment, the survival at a year was less than a third part of the whole series.
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2. Pérez Gracia JL, López Picazo JM, Martín Algarra S, Viteri S, García Foncillas J, Gúrpide A. Carcinoma microcítico de pulmón. Rev Med Univ Navarra. 2007 [citado 2 Feb 2015]; 51(2). Disponible en: https://www.researchgate.net/profile/Salvador_Martin-Algarra/publication/28183932_Carcinoma_microctico_de_pulmn/links/0deec51e995e6254eb000000.pdf
3. Emin Erbaycu A, Gunduz A, Batum O, Zeren Ucar Z, Tuksavul F, Zeki Guclu S. Valores pretratamiento e inducidos por el tratamiento de enolasa específica de neurona en pacientes con cáncer de pulmón microcítico: estudio prospectivo, abierto. Arch Bronconeumol. 2010 [citado 2 Feb 2015]; 46(7). Disponible en: http://www.archbronconeumol.org/es/valores-pretratamiento-e-inducidos-por/articulo/S0300289610001079/
4. Apolinario Hidalgo R. Actitud del internista ante neoplasia de origen desconocido. Actas del XXXII Congreso Nacional de la SEMI y XIV Congreso de la Sociedad Canaria de Medicina Interna; 26-28 Oct 2011; Las Palmas, Gran Canaria. Gran Canaria: SEMI; 2011 [citado 2 Feb 2015]. Disponible en: http://docplayer.es/776125-Actitud-del-internista-ante-la-neoplasia-de-origen-desconocido-rosa-apolinario-hidalgo-servicio-de-medicina-interna-hospital-insular-de-gran-canaria.html
5. Añel Rodríguez RM, Astigarraga Mallagaray E, García Pérez FJ. Carcinoma microcítico de pulmón. FMC. 2013; 20(6): 337-41.
6. Cobo Dols M, Gill Calle S, Villar Chamorro E, Alcaide García J, Alés Díaz I, Montesa Pino A, et al. Actualización en el tratamiento sistémico del carcinoma microcítico de pulmón. Oncología. 2005 [citado 20 Feb 2015]; 28(10). Disponible en: http://scielo.isciii.es/pdf/onco/v28n10/02.pdf
7. Anbazhagan R1, Tihan T, Bornman DM, Johnston JC, Saltz JH, Weigering A, et al. Classification of small cell lung cancer and pulmonary carcinoid by gene expression profiles. Cancer Res. 1999; 59(20):5119-22.
8. Toirac Lamarque RE. Protocolo de diagnóstico y tratamiento del cáncer pulmonar. Santiago de Cuba: [s.n.]; 1993.
9. Herrera Alemán F. Actualidades en el diagnóstico y tratamiento del cáncer de pulmón. Rev Med Hondur. 2011 [citado 2 Feb 2015]; 79(1). Disponible en: http://cidbimena.desastres.hn/RMH/pdf/2011/pdf/Vol79-1-2011-8.pdf
10. Herrera Villalobo C, Rodríguez Vázquez JC, Gassiot Nuño C, Pino Alfonso PP, Cid Guedes A. Influencia de la demora en el diagnóstico y el tratamiento en la supervivencia de pacientes con cáncer pulmonar. Rev Cubana Med. 2007 [citado 20 Feb 2015]; 46(1). Disponible en: http://scielo.sld.cu/scielo.php?pid=S0034-75232007000100008&script=sci_arttext
11. Garrido López P, Murcia Simón M, López Miranda E. Carcinoma microcítico de pulmón. En: Cortes Funes A, Colomer Bosch R, Alba Conejo E, Díaz Rubio E, González Barón M, Guillem Porta V, et al. Tratado de oncología. T 1. Barcelona: Publicaciones Permayer; 2009. p. 661-78.
12. Brahmer JR, Ettinger DS. Carboplatin in the treatment of lung cancer. Oncologist. 1998; 3(3): 143-54.
13. Gómez Herrero D, Alberti Marí A, Merino Sanjuán M, Boquera Ferrer ML, Jiménez Torres NV. Perfil de toxicidad y adherencia del esquema farmacoterapéutico gemcitabina-carboplatino en cáncer de pulmón no microcítico. Farm Hosp. 2011; 35(6): 298-304.
14. Navarro Expósito F, López González JL, Molina Villaverde R, Álvarez Mon Soto M. Cáncer microcítico de pulmón. Medicine. 2013; 11(4): 1441-6.
15. Cebollero Presmanes M, Sánchez Mora N, García Gómez R, Herranz Aladro ML, Álvarez Fernández E. Valor pronóstico de la expresión y amplificación genética de c-erbB-2 en el carcinoma microcítico de pulmón. Arch Bronconeumol. 2008; 44(3): 122-6.
16. Morales Sánchez L, Gassiot Nuño C, Nenínger Vinageras E, Prior García A, Rodríguez Vázquez JC. Supervivencia de pacientes con carcinoma broncógeno en el Hospital “Hermanos Ameijeiras” de 1997-2002. Rev Cubana Med. 2009 [citado 20 Feb 2015]; 48(3): 48-53. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232009000300002
17. Santos AO, Pereira JP, Pedroso de Lima MC, Simões S, Moreira JN. In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability. Braz J Med Biol Res. 2010 [citado 14 Ago 2014]; 43(10). Disponible en: http://www.scielo.br/scielo.php?pid=S0100-879X2010001000013&script=sci_arttext&tlng=pt
18. Lequaglie C, Patriarca C, Cataldo I, Muscolino G, Preda F, Ravasi G. Prognosis of resected well-differentiated neuroendocrine carcinoma of the lung. Chest. 1991; 100(4): 1053-6.
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