Mucin histochemistry demonstration for the differential diagnosis of prostate benign and malign lesions
Keywords:
prostate cancer, histochemistry stain, prostatic hyperplasia, pathologic diagnosis.Abstract
A comparative analytical study of 553 biopsies was carried out in “Dr. Juan Bruno Zayas Alfonso” Teaching General Hospital in Santiago de Cuba during 2014-2015, aimed at valuating the usefulness of mucin histochemistry stains: PAS, alcian blue (2.5 pH) and PAS-alcian blue, to differentiate the prostate benign and malign lesions. In the series, 98.4% of positive benign hyperplasias with PAS was obtained and none of them with alcian blue, while 50.9% of all carcinomas were positive with the latter; on the contrary, for the well differentiated carcinomas, the positivity with alcian blue was 96.3% and just 3.6% with PAS. It was concluded that mucin histochemistry stains can be used as tools to distinguish the well differentiated adenocarcinoma from the prostatic hyperplasia.
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