Fluids administration to seriously ill patients and its relationship with mortality
Keywords:
fluid therapy, serious state of the patient, water electrolyte balance, mortality.Abstract
Introduction: Fluids administration constitutes one of the treatment pillars in patients admitted to Intensive Care Unit in which the inadequate reanimation and overload of volume worsen the prognosis.
Objective: To characterize the state of fluid administration to patients admitted to the Intensive Cares Units of Dr. Antonio Luaces Iraola Teaching General Hospital in Ciego de Ávila and its relationship with mortality.
Methods: An analytic and prospective descriptive study of 147 patients admitted to the Intensive Cares Units of Dr. Antonio Luaces Iraola Teaching General Hospital was carried out in Ciego de Ávila during the first semester of 2020, for which 598 tests of fluids, some hemodynamic variables and the balance of liquids were evaluated in the first 72 hours of admission.
Results: The average age was 48.3 years, there was a prevalence of women (55.8 %), the punctuation of APACHE II at admission was 14.2 points and 22.4 % of those affected died. To administer fluids the clinical approach prevailed (57.2 %); while the central venous pressure, heart frequency, the mean arterial pressure and diuresis were similar in alive and dead patients. The accumulated balance of fluids was significantly higher in the group of dead patients (1984.70 mL vs 260 mL).
Conclusions: The changes in the vital parameters after administering fluids were not useful to evaluate the response to the volume. The accumulated balance of fluids was related to mortality in a significant way.
Downloads
References
2. Martin ND, Codner P, Greene W, Brasel K, Michetti C. Contemporary hemodynamic monitoring, fluid responsiveness, volume optimization, and endpoints of resuscitation: an AAST critical care committee clinical consensus. Trauma Surg Acute Care Open [citado 11/03/2020];5(1). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066619/
3. Nieto OR, Sánchez JS, Solórzano A, Márquez E, García OF, Zamarrón EI, et al. Fluidoterapia intravenosa guiada por metas. Med Int Méx. 2019 [citado 30/09/2020];35(2):235-50.Disponible en: https://www.medigraphic.com/pdfs/medintmex/mim-2019/mim192g.pdf
4. Li DK, Du W. Central venous pressure value can assisting adjust in norepinephrine dosage after the initial resuscitation of septic shock. Chin Med J. 2019 [citado 20/05/2020];132:1159-65. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511425/
5. Bennett VA, Vidouris A, Cecconi M. Effects of Fluids on the macro-and microcirculations. Crit Car. 2018 [citado 20/05/2020];22:74 Disponible en: https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-018-1993-1.pdf
6. Martos Benítez FD, Guzmán Breff BI. Expansión del volumen y variación en los parámetros hemodinámicos. Emerg. 2018 [citado 30/03/2020];30(3):177-81. Disponible en: https://medes.com/publication/134714
7. Zhang Z, Chen L. The association between fluid balance and mortality in patients with ARDS was modified by serum potassium levels: a retrospective study. Peer J. 2015 [citado 10/02/2020; 3. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327251/pdf/peerj-03-752.pdf
8. Chen H, Wu B, Gong D, Liu Z. Fluid overload at start of continuous renal replacement therapy is associated with poorer clinical condition and outcome: a prospective observational study on the combined use of bioimpedance vector analysis and serum N-terminal pro-B-type natriuretic peptide measurement. Crit Care. 2015 [citado 01/12/2020];19(1):135. Disponible en: https://ccforum.biomedcentral.com/articles/10.1186/s13054-015-0871-3
9. Vergouw L, Egal M, Bergmans B, Dippel D, Lingsma H, Vergouwen M, et al. Early Fluid Input After Aneurysmal Subarachnoid Hemorrhage: Combined Report of Association With Delayed cerebral Ischemia and Feasibility of Cardiac Output–Guided Fluid Restriction. J Int Care Med. 2020 [citado 22/09/2020];35(2)161-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28934895/
10. Gad MM, Simons Linares CR. Is aggressive intravenous fluid resuscitation beneficial in acute pancreatitis? A meta-analysis of randomized control trials and cohort studies. World J Gastroenterol. 2020 [citado 14/02/2020]; 26(10): 1098-1106. Disponible en: https://www.wjgnet.com/1007-9327/full/v26/i10/1098.htm
11. Mansoori JN, Linde Zwirble W, Hou PC, Havranek EP, Douglas IS. Variability in usual care fluid resuscitation and risk-adjusted outcomes for mechanically ventilated patients in shock. Crit Care. 2020 [citado 28/01/2020];24(1):25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31992351/
12. Da Silva SC, Consolim Colombo FM, Gomes Rodrigues R, Gaiotto FA, Abrahão Hajjar L, Affonso Moysés RM, et al. Fluid overload after coronary artery bypass graft in patients on maintenance hemodialysis is associated with prolonged time on mechanical ventilation. BMC Anesthesiol. 2020 [citado 30/01/2020];20(1):60. Disponible en: https://bmcanesthesiol.biomedcentral.com/track/pdf/10.1186/s12871-020-00971-6.pdf
13. Shahn Z, Shapiro N, Tyler PD, Talmor D, Lehman LW. Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis. Crit Care. 2020 [citado 22/02/2020];24(1):62. Disponible en: https://doi.org/10.1186/s13054-020-2767-0.
14. Åkerberg D, Ansari D, Bergenfeldt M, Andersson R, Tingstedt B. Early postoperative fluid retention is a strong predictor for complications after pancreatoduodenectomy. HPB. 2019 [citado 01/06/2020];21(12):1784-9. Disponible en: https://www.sciencedirect.com/science/article/pii/S1365182X19305428
15. Casas Aparicio GA, León Rodríguez I, Hernández Zenteno RJ, Castillejos López M, Alvarado de la Barrera C, Ormsby CE, et al. Aggressive fluid accumulation is associated with acute kidney injury and mortality in a cohort of patients with severe pneumonia caused by influenza A H1N1 virus. PLOS ONE. 2018 [citado 15/02/2018]. 2018; 13(2). Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192592
Published
How to Cite
Issue
Section
License
All the articles can be downloaded or read for free. The journal does not charge any amount of money to the authors for the reception, edition or the publication of the articles, making the whole process completely free. Medisan has no embargo period and it is published under the license of Creative Commons, International Non Commercial Recognition 4.0, which authorizes the copy, reproduction and the total or partial distribution of the articles in any format or platform, with the conditions of citing the source of information and not to be used for profitable purposes.