Inflammatory hematological markers associated with serious perioperative adverse events in cardiovascular surgery

Abstract

Introduction: The cardiovascular surgery bears a high morbidity and mortality for its nature, as well as high costs, therefore, the search of predictive tools of adverse events and perioperatory complications continue being object of clinical investigation.

Objective: To evaluate the relationship between selected inflammatory hematologic biomarkers with the emergence of perioperatory serious adverse events of the cardiovascular surgery.

Method: A design of ambispective cohort was implemented that included patients surgically intervened by cardiovascular affections during five years in the Cardiocenter from Santiago de Cuba. The studied variables were means in clinical different moments, and statistical methods were used as the bivariate analysis and relative risk, to determine the most outstanding relationships.

Results: Although the metabolic alterations and of the hydromineral balance and acid-basic were the more prevalent adverse events (68.0 %) in this surgery type, those that had a significant association with the severity were the mechanical complications (p=0000), electric (p=0002) and the neurological dysfunctions (p=0019), a narrow connection was evidenced (p=0000) of the selected biomarkers with the adverse events related with the surgical procedure.

Conclusions: The frequency of serious perioperatory adverse events is compatible with that pointed out in the national and international bibliography and a narrow relationship of them is revealed with the new hematological inflammatory markers studied, therefore they could be very useful to reinforce the surveillance, precocious diagnosis and therapy of complications and to revert the high morbidity and mortality of  these patients.